Table 5.
Association of clinico-pathological factors with overall survival in univariable and multivariable Cox proportional hazard analysis.
| Censored (n=1607) | Died (n= 576) | Univariable | Multivariable (n = 1648) | |||
|---|---|---|---|---|---|---|
| Factor | n (%) | n (%) | Hazard ratio (95% CI) | p | Hazard ratio (95% CI) |
p |
| Breslow (mm) | - | - | 1.21 (1.19, 1.24) | <0.001 | 1.20 (1.16, 1.24) | <0.001 |
| Age (years) | - | - | 1.05 (1.04, 1.10) | <0.001 | 1.05 (1.04, 1.06) | <0.001 |
| Sex | ||||||
| Female | 968(79) | 265 (21) | 1 | - | 1 | - |
| Male | 639 (67) | 311 (33) | 1.68 (1.42, 1.98) | <0.001 | 1.41 (1.12, 1.78) | 0.004 |
| Tumor site | ||||||
| Limbs | 825(81) | 190 (19) | 1 | - | 1 | - |
| Back | 387 (71) | 158 (29) | 1.60 (1.29, 1.98) | <0.001 | 1.36 (1.05, 1.76) | 0.02 |
| Trunk | 151(70) | 64 (30) | 1.98 (1.26, 2.23) | <0.001 | 1.35 (0.96, 1.91) | 0.09 |
| Head/neck | 141 (67) | 71 (33) | 1.69 (1.27, 2.22) | <0.001 | 0.98 (0.71, 1.35) | 0.90 |
| Acral/sun protected | 103(53) | 93 (47) | 3.54 (2.76, 4.53) | <0.001 | 1.22 (0.85, 1.76) | 0.29 |
| Vitamin D1 nmol/L | ||||||
| 20–60 | 870(73) | 319 (27) | 1 | - | 1 | - |
| <20 | 69(63) | 41 (37) | 1.52 (1.10, 2.11) | 0.01 | 1.57 (1.10, 2.25) | 0.01 |
| >60 | (370 (77) | 111 (23) | 0.83 (0.67, 1.03) | 0.08 | 0.79 (0.62, 1.00) | 0.05 |
| Townsend score | ||||||
| Least deprived | 522 (75) | 177 (25) | 1 | - | 1 | - |
| Moderate | 542 (75) | 185 (25) | 0.96 (0.78, 1.12) | 0.68 | 1.05 (0.88, 1.361 | 0.67 |
| Most deprived | 508 (71) | 206 (29) | 1.10 (0.90, 1.35) | 0.34 | 0.97 (0.76, 1.25) | 0.83 |
| WHO 25×25 factors | ||||||
| Smoking | ||||||
| Never | 897(78) | 260 (22) | 1 | - | 1 | - |
| Ex smoker | 485(70) | 211 (30) | 1.42 (1.18, 1.70) | <0.001 | 1.09 (0.88, 1.36) | 0.42 |
| Smoker | 169 (69) | 75 (31) | 1.31 (1.01, 1.69) | 0.04 | 1.66 (1.21, 2.28) | 0.002 |
| BMI | - | - | 1.02 (1.00, 1.04) | 0.03 | 1.00 (0.98, 1.02) | 0.84 |
| Alcohol intake units/week | ||||||
| 0 | 284 (69) | 126 (31) | 1.28 (1.01, 1.64) | 1.08 (0.81, 1.44) | 0.60 | |
| >0 ≤7 | 426 (76) | 134 (24) | 1 | - | 1 | - |
| >7 ≤14 | 324 (75) | 106 (25) | 1.04 (0.81, 1.35) | 0.74 | 1.00 (0.75, 1.35) | 0.99 |
| >14 | 509 (75) | 173 (25) | 0.96 (0.77, 1.20) | 0.72 | 0.79 (0.59, 1.06) | 0.12 |
| Exercise MET2 hrs/week | ||||||
| 0 | 388 (73) | 146 (27) | 1 | - | 1 | - |
| 0.1 – 10 | 356 (74) | 125 (26) | 0.98 (0.77, 1.25) | 0.88 | 0.99 (0.75, 1.30) | 0.92 |
| 10.1 – 20 | 431 (74) | 150 (26) | 0.98 (0.78, 1.24) | 0.90 | 0.87 (0.67, 1.17) | 0.39 |
| >20 | 361(75) | 119 (25) | 0.98 (0.77, 1.25) | 0.88 | 0.97 (0.73, 1.29) | 0.84 |
1
Vitamin D adjusted for season and batch.
2
Metabolic Equivalence of Task