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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Hum Genet. 2019 Dec 3;139(2):151–184. doi: 10.1007/s00439-019-02095-5

Fig. 4. In silico subtraction effectively prioritizes cataract associated genes.

Fig. 4.

(A) Comparison of top 30 lens enriched proteins with the top 30 lens “expressed” proteins shows that in silico WB-subtraction is effective in identifying the Crystallins as well as several other cataract associated factors such as Aldh1a1, Bfsp1, Bfsp2, Caprin2, Cryab, Crygs, Gja8, Lama1, Mip, Prox1 and Tdrd7 (grey). (B) Top cataract associated proteins that were not present in the top 30 “expressed” candidates show significant (p<0.001) enrichment in the lens compared to WB. This shows that the in silico WB-subtraction strategy is effective in identifying these important non-crystallin lens proteins. The y-axis represents the average SpC individual proteins.