Skip to main content
. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Hum Genet. 2019 Dec 3;139(2):151–184. doi: 10.1007/s00439-019-02095-5

Table 3.

Top 150 expressed proteins in the E14.5 mouse lens

SN UniProt Gene Name Primary Protein Name Avg. Lens
1 Crybb1 Beta-crystallin B1B 543.4
2 Cryaa Alpha-crystallin A chain 517.7
3 Sptan1 Spectrin alpha chain, non-erythrocytic 1 365.8
4 Crygf Gamma-crystallin F 348.9
5 Vim Vimentin 346.1
6 Crybb3 Beta-crystallin B3, N-terminally processed 340.8
7 Hsp90ab1 Heat shock protein HSP 90-beta 325.5
8 Hspa8 Heat shock cognate 71 kDa protein 285.2
9 Cryba1 Beta-crystallin A1 284.6
10 Eno1 Alpha-enolase 276.5
11 Cryga Gamma-crystallin A 257.4
12 Crygd Gamma-crystallin D 256.7
13 Crygb Gamma-crystallin B 237.3
14 Plec Plectin (PCN; PLTN) 210.5
15 Flna Filamin-A (FLN-A) 209.0
16 Sptbn1 Spectrin beta chain, non-erythrocytic 1 203.8
17 Eef2 Elongation factor 2 (EF-2) 203.8
18 Pkm Pyruvate kinase PKM 184.1
19 Crygc Gamma-crystallin C 171.9
20 Hspd1 60 kDa heat shock protein, mitochondrial 171.6
21 Vcp Transitional endoplasmic reticulum ATPase (TER ATPase) 167.0
22 Hsp90aa1 Heat shock protein HSP 90-alpha 133.5
23 Hspa5 Endoplasmic reticulum chaperone BiP 129.8
24 Cryba2 Beta-crystallin A2 127.8
25 Capn3 Calpain-3 127.5
26 Fasn Oleoyl-[acyl-carrier-protein] hydrolase 125.8
27 Myh9 Myosin-9 112.3
28 Ywhae 14-3-3 protein epsilon (14-3-3E) 112.1
29 Ezr Ezrin 108.9
30 Hbb-bs Beta-globin 108.5
31 Hsp90b1 Endoplasmin 107.4
32 Lmnb1 Lamin-B1 106.7
33 Cryba4 Beta-crystallin A4 106.3
34 Tkt Transketolase (TK) 105.5
35 Ipo5 Importin-5 (Imp5) 104.3
36 Hnrnpa2b1 Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) 103.7
37 Aldh1a1 Retinal dehydrogenase 1 (RALDH 1; RalDH1) 100.7
38 Gsn Gelsolin 99.2
39 Ank2 Ankyrin-2 (ANK-2) 97.9
40 Hnrnpk Heterogeneous nuclear ribonucleoprotein K (hnRNPK) 96.2
41 Dync1h1 Cytoplasmic dynein 1 heavy chain 1 94.3
42 Atp5f1a ATP synthase subunit alpha, mitochondrial 91.6
43 Rps3 40S ribosomal protein S3 90.4
44 Uba1 Ubiquitin-like modifier-activating enzyme 1 88.0
45 Pgk1 Phosphoglycerate kinase 1 87.6
46 Pdia3 Protein disulfide-isomerase A3 87.3
47 Afp Alpha-fetoprotein 87.0
48 Ywhaz 14-3-3 protein zeta/delta 86.7
49 Aldoa Fructose-bisphosphate aldolase A 85.7
50 Hspa4 Heat shock 70 kDa protein 4 85.2
51 Ncl Nucleolin 84.3
52 Sptbn2 Spectrin beta chain 83.0
53 Tcp1 T-complex protein 1 subunit alpha (TCP-1-alpha) 82.4
54 P4hb Protein disulfide-isomerase (PDI) 79.9
55 Atp2a2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2; SR Ca(2+)-ATPase 2) 78.7
56 Calr Calreticulin 76.2
57 Hnrnpu Heterogeneous nuclear ribonucleoprotein U (hnRNPU) 76.2
58 Tdrd7 Tudor domain-containing protein 7 75.8
59 Cryab Alpha-crystallin B chain 75.6
60 Cct5 T-complex protein 1 subunit epsilon (TCP-1-epsilon) 75.0
61 Gja8 Gap junction alpha-8 protein 74.5
62 Rps3a 40S ribosomal protein S3a 70.6
63 Bfsp1 Filensin 69.6
64 Naca Nascent polypeptide-associated complex subunit alpha, muscle-specific form 69.3
65 Basp1 Brain acid soluble protein 1 68.6
66 Khsrp Far upstream element-binding protein 2 (FUSE-binding protein 2) 68.2
67 Cct3 T-complex protein 1 subunit gamma (TCP-1-gamma) 66.9
68 Vdac1 Voltage-dependent anion-selective channel protein 1 (VDAC-1; mVDAC1) 66.9
69 Cct6a T-complex protein 1 subunit zeta (TCP-1-zeta) 66.9
70 Marcksl1 MARCKS-related protein 66.5
71 Pcbp1 Poly(rC)-binding protein 1 66.2
72 Cct8 T-complex protein 1 subunit theta (TCP-1-theta) 66.0
73 Rack1 Gnb2l1 Receptor of activated protein C kinase 1, N-terminally processed 64.7
74 Crygn Gamma-crystallin N 64.7
75 Tuba1a Detyrosinated tubulin alpha-1A chain 64.6
76 Ppia Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 64.2
77 Tuba1c Detyrosinated tubulin alpha-1C chain 63.8
78 Hspa9 Stress-70 protein, mitochondrial 63.0
79 Cct7 T-complex protein 1 subunit eta (TCP-1-eta) 62.7
80 Hist1h4a Histone H4 62.4
81 Ywhaq 14-3-3 protein theta 60.8
82 Gdi2 Rab GDP dissociation inhibitor beta (Rab GDI beta) 60.6
83 Pgam1 Phosphoglycerate mutase 1 60.2
84 Rplp2 60S acidic ribosomal protein P2 59.9
85 Pa2g4 Proliferation-associated protein 2G4 59.6
86 Tln1 Talin-1 59.4
87 Trim28 Transcription intermediary factor 1-beta (TIF1-beta) 59.0
88 Nap1l4 Nucleosome assembly protein 1-like 4 58.7
89 Ctnna1 Catenin alpha-1 58.4
90 Snd1 Staphylococcal nuclease domain-containing protein 1 57.7
91 Prdx1 Peroxiredoxin-1 57.7
92 Ywhah 14-3-3 protein eta 57.2
93 Pdia6 Protein disulfide-isomerase A6 56.3
94 Bfsp2 Phakinin 55.7
95 Ckb Creatine kinase B-type 55.4
96 Kpnb1 Importin subunit beta-1 55.3
97 Eef1g Elongation factor 1-gamma (EF-1-gamma) 55.2
98 Pdia4 Protein disulfide-isomerase A4 55.1
99 Cct4 T-complex protein 1 subunit delta (TCP-1-delta) 54.9
100 Ckap4 Cytoskeleton-associated protein 4 54.5
101 Ybx1 Nuclease-sensitive element-binding protein 1 54.0
102 Fubp1 Far upstream element-binding protein 1 (FBP; FUSE-binding protein 1) 54.0
103 Prdx2 Peroxiredoxin-2 53.8
104 Marcks Myristoylated alanine-rich C-kinase substrate (MARCKS) 53.6
105 Eif2s1 Eukaryotic translation initiation factor 2 subunit 1 53.5
106 Nsfl1c NSFL1 cofactor p47 53.5
107 Hmgb1 High mobility group protein B1 53.5
108 Npm1 Nucleophosmin (NPM) 53.0
109 Ptbp1 Polypyrimidine tract-binding protein 1 (PTB) 52.6
110 Pygm Glycogen phosphorylase, muscle form 52.1
111 Fkbp4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 51.7
112 Hnrnpm Heterogeneous nuclear ribonucleoprotein M (hnRNPM) 50.9
113 Sptb Spectrin beta chain, erythrocytic 50.6
114 Gss Glutathione synthetase (GSH synthetase; GSH-S) 50.5
115 Sfpq Splicing factor, proline- and glutamine-rich 50.3
116 Cap1 Adenylyl cyclase-associated protein 1 (CAP 1) 50.0
117 Npl N-acetylneuraminate lyase (NALase) 50.0
118 Tpi1 Triosephosphate isomerase (TIM) 49.6
119 Caprin2 Caprin-2 48.5
120 Rpsa 40S ribosomal protein SA 48.0
121 Tjp1 Tight junction protein ZO-1 47.9
122 Pfn1 Profilin-1 47.4
123 Nono Non-POU domain-containing octamer-binding protein (NonO protein) 46.5
124 Eprs Proline--tRNA ligase 46.3
125 Hba Hemoglobin subunit alpha 46.2
126 Rpl12 60S ribosomal protein L12 45.5
127 Acta1 Actin, alpha skeletal muscle, intermediate form 45.4
128 Mdh2 Malate dehydrogenase, mitochondrial 45.2
129 Epb41l2 Band 4.1-like protein 2 45.0
130 Rps4x 40S ribosomal protein S4, X isoform 44.7
131 Phgdh D-3-phosphoglycerate dehydrogenase (3-PGDH) 44.7
132 Nedd4 E3 ubiquitin-protein ligase NEDD4 44.6
133 Pabpc1 Polyadenylate-binding protein 1 (PABP-1; Poly(A)-binding protein 1) 43.8
134 Rps8 40S ribosomal protein S8 43.6
135 Rps18 40S ribosomal protein S18 43.4
136 Psmd1 26S proteasome non-ATPase regulatory subunit 1 43.3
137 Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) 43.2
138 Dars Aspartate--tRNA ligase, cytoplasmic 43.1
139 Dbnl Drebrin-like protein 42.8
140 Ran GTP-binding nuclear protein Ran 42.7
141 Vars Valine--tRNA ligase 42.5
142 Hnrnpa1 Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 42.5
143 Serbp1 Plasminogen activator inhibitor 1 RNA-binding protein 42.4
144 Rps14 40S ribosomal protein S14 42.1
145 Rps27a 40S ribosomal protein S27a 42.1
146 Hbb-y Hemoglobin subunit epsilon-Y2 41.8
147 Ywhag 14-3-3 protein gamma, N-terminally processed 41.7
148 Hnrnpa3 Heterogeneous nuclear ribonucleoprotein A3 (hnRNPA3) 41.6
149 Rpl3 60S ribosomal protein L3 41.6
150 Idh2 Isocitrate dehydrogenase [NADP], mitochondrial (IDH) 41.4