Fig. 4.

Partial superpositions of individual subunits of unliganded and propylammonium-bound ELIC. (A and B) One subunit from each of the structural models of POPC-embedded ELIC was extracted from the pentameric assembly, and the two were superposed partially using either the ECD (residues 11 to 199; A) or the TMD (excluding the M3–M4 linker and M4; residues 200 to 280; B) as the fragments over which Cα–Cα distances were minimized. The models are displayed in cartoon representation. The color code is the same for both panels. Molecular images were prepared with VMD (37). NDs: nanodiscs.