Table 1.

Selected expression-changed genes which may contribute to drug resistance in cox10 mutants

Gene name (A. f /S. c)	Gene ID	Description	Fold changes (log2)
			Δcox10/WT	R243Q/WT
		Calcium-signaling/homeostasis related genes
pmcC/pmc1	AFUB_087610	Calcium transporting ATPase (Pmc1)	10.10 ± 2.84	5.25 ± 2.47
tpo3/tpo3	AFUB_101650	Crz1 target, MFS multidrug transporter	7.89 ± 1.62	4.03 ± 0.77
zfpA/ace2	AFUB_082490	Crz1 target, C2H2 finger domain protein	3.34 ± 0.61	2.12 ± 0.35
pmcB/pmc1	AFUB_038470	Calcium-translocating P-type ATPase	2.85 ± 1.87	1.39 ± 0.42
mcuA	AFUB_067410	Conserved protein	1.15 ± 0.64	−0.22 ± 1.37
pmcA/pmc1	AFUB_010300	P-type calcium ATPase	0.91 ± 0.60	0.15 ± 0.54
		Multidrug transport related genes
mdr1/ste6	AFUB_053630	ABC multidrug transporter Mdr1	7.46 ± 0.55	1.42 ± 1.72
atrB/snq2	AFUB_047000	ABC multidrug transporter, putative	6.40 ± 0.79	2.93 ± 0.69
atrA/pdr15	AFUB_041770	ABC multidrug transporter, putative	4.85 ± 0.66	3.04 ± 0.77
atrF/snq2	AFUB_093930	ABC drug exporter AtrF	2.72 ± 1.16	1.08 ± 0.04
abcE/ste6	AFUB_087060	ABC multidrug transporter, putative	2.55 ± 0.16	1.54 ± 0.59
abcC/pdr15	AFUB_013880	ABC transporter, putative	1.99 ± 0.63	1.09 ± 0.99
		Chitin synthase genes
chsA/chs1	AFUB_018960	Putative class I chitin synthase	1.99 ± 0.59	1.06 ± 0.05
chsE/chs3	AFUB_029080	Putative class V chitin synthase	1.71 ± 0.91	1.39 ± 0.19
csmB/chs3	AFUB_029070	Putative chitin synthase	0.94 ± 0.46	0.56 ± 0.26
chsD/chs3	AFUB_012070	Putative chitin synthase-like gene	0.86 ± 1.04	1.05 ± 0.74
chsC/chs2	AFUB_049230	Putative class III chitin synthase	0.82 ± 0.61	0.70 ± 0.22
		Catalases
easC/cta1	AFUB_033720	Catalase easC	−6.29 ± 1.56	−0.07 ± 0.33
catB/cta1	AFUB_046060	Mycelial catalase Cat1	−3.54 ± 1.77	−2.70 ± 0.83
cat2/ccp1	AFUB_084930	Bifunctional catalase-peroxidase Cat2	−1.35 ± 1.17	−0.21 ± 0.28

A. f, A. fumigatus; S. c, S. cerevisiae; R243Q, Cox10^R243Q.