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. 2020 Jan 3;117(3):1658–1665. doi: 10.1073/pnas.1914949117

Fig. 4.

Fig. 4.

Genomic distributions of (A) eccDNA and (B) linear DNA in maternal plasma. Plasma DNA samples from five pregnant subjects were analyzed for each groups. Data of eccDNA were obtained from the tagmentation approach. The “normalized genomic coverage” of linear/eccDNA for each class of genomic elements is the percentage of DNA molecules mapped to that class of genomic elements divided by the percentage of the genome covered by that class of elements. CpG2kbD, 2 kb downstream of CpG islands; CpG2kbU, 2 kb upstream of CpG islands; Gene2kbD, 2 kb downstream of genes; Gene2kbU, 2 kb upstream of genes; UTR, untranslated region.