Table 2.
CF carriers and subjects with CF are more likely to experience multiple CF-related conditions, and conditions that affect multiple organ systems, compared with controls
| Parameter | CF carriers, n (%) | Controls, n (%) | OR (95% CI) | CF, n (%) | Controls, n (%) | OR (95% CI) |
| Conditions | ||||||
| 0 | 5,819 (29.39) | 38,286 (38.67) | 0.61 (0.59–0.63) | 1,734 (7.36) | 55,564 (47.18) | 0.06 (0.06–0.06) |
| 1–2 | 7,895 (39.87) | 36,007 (36.37) | 1.16 (1.13–1.2) | 4,634 (19.67) | 39,644 (33.66) | 0.48 (0.46–0.49) |
| 3–4 | 3,589 (18.12) | 15,246 (15.40) | 1.23 (1.18–1.28) | 4,361 (18.51) | 14,268 (12.12) | 1.69 (1.63–1.75) |
| 5–6 | 1,529 (7.72) | 6,057 (6.12) | 1.30 (1.22–1.38) | 3,668 (15.57) | 5,316 (4.51) | 4.17 (3.98–4.37) |
| 7–8 | 603 (3.05) | 2,206 (2.23) | 1.39 (1.27–1.53) | 2,845 (12.08) | 1,921 (1.63) | 8.91 (8.37–9.48) |
| 9–10 | 222 (1.12) | 824 (0.83) | 1.36 (1.17–1.58) | 2,077 (8.82) | 668 (0.57) | 18.12 (16.53–19.87) |
| >10 | 145 (0.73) | 384 (0.39) | 1.91 (1.57–2.31) | 4,238 (17.99) | 381 (0.32) | 89.1 (78.97–100.54) |
| Organ systems | ||||||
| 0 | 5,819 (29.39) | 38,286 (38.67) | 0.61 (0.59–0.63) | 1,734 (7.36) | 55,564 (47.18) | 0.06 (0.06–0.06) |
| 1 | 5,853 (29.56) | 27,644 (27.92) | 1.08 (1.05–1.12) | 3,081 (13.08) | 31,140 (26.44) | 0.41 (0.4–0.43) |
| 2 | 4,111 (20.76) | 17,604 (17.78) | 1.22 (1.17–1.27) | 4,005 (17.00) | 17,449 (14.82) | 1.18 (1.14–1.23) |
| 3 | 2,311 (11.67) | 9,258 (9.35) | 1.30 (1.23–1.36) | 4,004 (17.00) | 8,156 (6.93) | 2.87 (2.76–3) |
| 4 | 1,076 (5.43) | 4,037 (4.08) | 1.37 (1.27–1.47) | 3,560 (15.11) | 3,580 (3.04) | 6.16 (5.85–6.48) |
| >4 | 632 (3.19) | 2,181 (2.20) | 1.48 (1.35–1.63) | 7,173 (30.45) | 1,873 (1.59) | 38.42 (36.03–40.96) |
ORs corresponding to the presence of a certain number of distinct conditions and the presence of a certain number of total organ systems affected are provided between CF carriers and controls and between subjects with CF and controls. Conditional logistic regression models were used to estimate the odds of a subject experiencing a given number of conditions/organ systems affected. For both CF carriers and subjects with CF, the relative odds of experiencing a given number of conditions or organ systems affected increased with the number of conditions/systems.