. 2020 Jan 20;12:73–81. doi: 10.2147/CLEP.S240006

Table 2.

Annual Change of Male-to-Female Age-Standardized Incidence Rate Ratio of Colorectal Cancer

Site	Age Group	Trend 1		Trend 2		Trend 3		Trend 4		Trend 5		AAPC^b (95% CI)
Years	APC^a (95% CI)	Years	APC^a (95% CI)	Years	APC^a (95% CI)	Years	APC^a (95% CI)	Years	APC^a (95% CI)
RCC	0–49 years	1960–2014	0.7^c (0.3, 1.1)									0.7^c (0.3, 1.1)
	>49 years	1960–1995	0.3^c (0.1, 0.5)	1995–2014	−1.1^c (−1.6, −0.6)							−0.2 (−0.4, 0.0)
	Overall	1960–1995	0.4^c (0.2, 0.5)	1995–2014	−1.0^c (−1.5, −0.6)							−0.1 (−0.3, 0.1)
LCC	0–49 years	1960–2014	0.6^c (0.1, 1.1)									0.6^c (0.1, 1.1)
	>49 years	1960–1973	−1.0 (−2.1, 0.0)	1973–2014	0.6^c (0.5, 0.8)							0.2 (−0.1, 0.5)
	Overall	1960–1974	−0.7 (−1.6, 0.2)	1974–2014	0.6^c (0.4, 0.8)							0.3^c (0.0, 0.6)
Rectum	0–49 years	1960–1978	2.3^c (0.9, 3.7)	1978–1985	−7.3^c (−13.7, −0.5)	1985–1988	19.8 (−21.2, 82.1)	1988–2007	−1.3 (−2.6, 0.1)	2007–2014	7.1^c (1.3, 13.3)	1.2 (−1.4, 3.9)
	>49 years	1960–1973	−0.8 (−1.6, 0.1)	1973–1976	7.8 (−8.1, 26.4)	1976–1979	−6.3 (−20.1, 9.9)	1979–2014	0.1 (−0.0, 0.3)			−0.0 (−1.3, 1.2)
	Overall	1960–1973	−0.6 (−1.3, 0.2)	1973–1976	7.6 (−7.3, 24.9)	1976–1979	−6.2 (−19.2, 8.9)	1979–2014	0.2 (−0.0, 0.3)			0.0 (−1.1, 1.2)

Notes: ^aAnnual percent change. ^bAverage annual percent change. ^cAPC or AAPC is significantly different from zero at α = 0.05.