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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Cell Calcium. 2019 Sep 16;83:102081. doi: 10.1016/j.ceca.2019.102081

Figure 6.

Figure 6.

Smaller steps reveal much more sophisticated modulation of responses in islets compared to dispersed beta-cells. (A) Example of an intact islets displaying glucose-induced changes in oscillatory intracellular calcium activity with each 2-mM glucose step from 8 to 10 and from 10 to 12mM. (B) Example of an oscillatory pattern in a dispersed beta-cell that appear unaffected by the same 2mM step changes in glucose which is considered non-glucose sensitive. (C) Example of oscillatory calcium activity of an individual beta-cell that glucose sensitive and is more in line with islet calcium patterns.