Table 3.
Multivariable model results for atorvastatin (ATV) analyte levels
| Model characteristic | ATV | 2‐OH ATV | ATV L | 2‐OH ATV L | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | B (SE) | I | P‐value | B (SE) | I | P‐value | B (SE) | I | P‐value | B (SE) | I | P‐value |
| ATV dose | 0.153 (0.058) | 0.68 | .0084 | 0.212 (0.048) | 1 | .000012 | 0.222 (0.064) | 1 | .00052 | 0.215 (0.051) | 1 | .000023 |
| Sex (F vs M) | −0.123 (0.034) | 1 | .00038 | ‐ | ‐ | ‐ | −0.097 (0.038) | 0.6 | .010 | ‐ | ‐ | ‐ |
| Age | 0.004 (0.001) | 1 | .0016 | 0.007 (0.001) | 1 | 6.30x10–8 | ‐ | ‐ | ‐ | 0.006 (0.001) | 1 | 3.80x10–7 |
| Body mass index | ‐ | ‐ | ‐ | −0.006 (0.002) | 0.82 | .0047 | −0.006 (0.003) | 0.36 | .016 | −0.006 (0.002) | 0.8 | .0059 |
| Smoking | ‐ | ‐ | ‐ | −0.076 (0.028) | 0.64 | .0066 | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ |
| Diabetes mellitus | ‐ | ‐ | ‐ | 0.079 (0.031) | 0.37 | .011 | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ |
| Chronic kidney disease | ‐ | ‐ | ‐ | 0.111 (0.051) | 0.05 | .030 | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ |
| Hepatic disease | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | −0.289 (0.134) | 0.16 | .032 |
| Loop diuretic | 0.099 (0.040) | 0.53 | .012 | 0.074 (0.033) | 0.06 | .025 | 0.121 (0.043) | 0.81 | .0044 | 0.084 (0.035) | 0.28 | .016 |
| Proton pump inhibitor | 0.093 (0.030) | 1 | .0016 | 0.062 (0.024) | 0.55 | .010 | 0.139 (0.033) | 1 | .000022 | 0.106 (0.026) | 1 | .000041 |
| CYP3A inhibitor | 0.166 (0.076) | 0.18 | .029 | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Amiodarone | 0.282 (0.129) | 0.1 | .029 | ‐ | ‐ | ‐ | 0.320 (0.142) | 0.18 | .024 | ‐ | ‐ | ‐ |
| Sample storage duration | ‐ | ‐ | ‐ | −0.0001 (0.00003) | 1 | 1.14x10–6 | 0.0002 (0.00004) | 1 | 4.00x10–9 | 0.0001 (0.00003) | 1 | 1.44x10–6 |
| Time since last ATV | −0.001 (0.0001) | 1 | <2.0x10–16 | −0.0007 (0.0001) | 1 | <2.0x10–16 | −0.0007 (0.0001) | 1 | 3.15x10–7 | −0.0006 (0.0001) | 1 | 2.00x10–8 |
| Num of models averaged | 7 | 13 | 8 | 4 | ||||||||
| R2 | 0.17 | 0.24 | 0.18 | 0.21 | ||||||||