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. 2020 Jan 22;147(2):dev180018. doi: 10.1242/dev.180018

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© 2020. Published by The Company of Biologists Ltd

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Fig. 1. — Ars2 is required for embryonic NSC development. (A) E15.5 ventral forebrain stained for Ars2 (green) shows it is expressed in the ventricular zone (VZ) enriched for SOX2 (red) and in postmitotic neurons in the striatum, but is downregulated in the subventricular zone (SVZ) region. DAPI (blue/grayscale) stains all nuclei. (B) Strategy to generate Ars2 conditional knockout mice using hGFAP-Cre. (C) Neurospheres (nsph.) from hGFAP-Cre; Ars2^fl/fl embryonic forebrain are significantly smaller. Arrows indicate representative neurospheres. n=9, two tailed t-test; data are mean±s.d.