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. 2020 Jan 8;147(1):dev181099. doi: 10.1242/dev.181099

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Aurora B is required for E8-E16 cytokinesis and epithelial polarization. Microtubule dynamics during the E8-E16 divisions. (A) Time line of embryonic divisions and shifts for temperature-sensitive mutants. (B-E) In wild-type (WT) embryos, spindle midzone microtubules (TBB-1::GFP, green; H2B::mCherry and PH::mCherry shown in magenta) form in late anaphase (arrowheads, C) and migrate to the apical midline (D) and persist (E). (F-I) In air-2(or207) embryos, spindle midzone microtubules are diminished (G, filled arrowhead). When cytokinesis failures occur (G,H, unfilled arrowheads), nuclei fail to reach the apical midline (G-I, red asterisks) and apical microtubule accumulation is reduced (dashed bracket indicates failed divisions, solid bracket indicates successful divisions with apical accumulation). Dashed boxes indicate gut cells. Scale bars: 10 μm.