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. 2020 Jan 8;147(1):dev181099. doi: 10.1242/dev.181099

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Aurora B is required for adhesion dynamics during E8-E16 cytokinesis. Adhesion dynamics during E8-E16 division and polarization. (A-D) HMP-1::GFP (green; microtubules in magenta) localizes to the furrow and midbody (B, arrowhead) during cytokinesis. HMP-1::GFP migrates with the midbody (C, arrowhead) to the apical surface where it accumulates after polarization (D). (E) Montage of HMP-1::GFP during E8-E16 division shows furrow and midbody (arrowheads) migration to the apical midline. (F-I) Aurora B mutants have reduced HMP-1::GFP on the furrow and midbody (F, unfilled arrowheads). When cells fail cytokinesis (G,H, unfilled arrowheads), HMP-1 accumulation is delayed (dashed bracket shows failed cytokinesis, solid bracket indicates successful E8 division with apical accumulation). Asterisks in H indicate nuclei. (I) HMP-1 signal eventually spreads along the midline. (J) Montage of HMP-1::GFP in Aurora B mutant E8-E16 cells that fail cytokinesis (unfilled arrowheads indicate furrow regression) and have delayed apical accumulation. Filled arrowheads indicate HMP-1 signal. Scale bars: 10 μm.