FIG. 1.

Heterogeneity and somatic mutations specific to primary, metastatic tumors, and shared between both lesions. (A) Number of somatic mutations identified in primary tumors and metastatic lesions. The dashed line shows a shared median of 24.5 mutations in both the primary tumors and the metastatic lesions. (B) Venn diagrams demonstrate the number of somatic mutations and likely pathogenic mutations specific to the primary tumor, metastases, and mutations present in both lesions. The number of likely pathogenic mutations is shown in parenthesis. Labeled genes with likely pathogenic mutations in noncancer genes are colored red, while those affecting cancer genes are colored blue. Color images are available online.