Figure 4.

Differentially expressed serum proteins in response to Rickettsia conorii infection. A: Venn diagram of the overlap of the differentially expressed serum proteins from three pairwise comparisons. Data are given for sublethal dose (SLD), lethal dose (LD), and control (Ctrl). B: Heat map of the expression of proteins that are differentially expressed in at least one pairwise comparison. Brown cluster, the proteins were down-regulated after R. conorii infection; blue cluster, the proteins were up-regulated by R. conorii and more so in mice with lethal dose; purple cluster, the proteins were up-regulated by sublethal dose of R. conorii. C and D: The expression of proteins involved in blood coagulation. E and F: The expression of proteins involved in the acute response. G: The expression of proteins involved in the removal of reactive oxygen species. H and I: The expression of proteins involved in the defense response. J: The abundance of intercellular adhesion molecule 1 in the plasma. n = 6 SLD (A); n = LD 3 (A); n = 5 Ctrl (A). **P < 0.01 versus control (t-test with permutation-based false discovery rate of <0.01 in the pairwise comparison). C2, complement C2; C9, complement component C9; C1QA, complement C1q subcomponent subunit A; C1QB, complement C1q subcomponent subunit B; C1QC, complement C1q subcomponent subunit C; CELA1, chymotrypsin-like elastase family member 1; HP, haptoglobin; ITIH4, inter-α-trypsin inhibitor heavy chain H4; KLKB1, plasma kallikrein; LBP, lipopolysaccharide-binding protein; LFQ, label-free quantification; MARCO, macrophage receptor MARCO; ORM, α-1-acid glycoprotein; PLG, plasminogen; PRDX, peroxiredoxin; PROS1, vitamin K-dependent protein S; PROZ, vitamin K-dependent protein Z; SAA, serum amyloid A; SERPINA3N, serine protease inhibitor A3N; SERPINC1, antithrombin-III; SERPIND1, heparin cofactor 2; SOD1, superoxide dismutase; VWF, von Willebrand factor.