Skip to main content
. 2020 Feb;190(2):306–322. doi: 10.1016/j.ajpath.2019.10.007

Figure 5.

Figure 5

Identification of plasma protein markers for Rickettsia conorii infection. A: Principal component analysis of plasma proteins that were significantly changed by sublethal dose (SLD) and lethal dose (LD) of R. conorii infection. Blue open squares are control animals (Ctrl), red solid circles are individual animals with SLD R. conorii infection, and green solid squares are animals with lethal dose R. conorii infection. B–H: Stable isotope dilution–selected reaction monitoring–mass spectrometry validation of plasma protein markers for R. conorii infection and the severity of the infection. n = 6 SLD (A); n = 3 LD (A); n = 5 Ctrl (A). *P < 0.05, ***P < 0.001 (t-test). A1BG, alpha-1B-glycoprotein; CKM, creatine kinase M-type; LCN2, neutrophil gelatinase-associated lipocalin; MUP8, major urinary protein 8; SAA, serum amyloid A; SIS, stable isotope labeled.