Table 1.
The Proteins with the Highest Discrimination Power between Rickettsia conorii–Infected HUVECs and Control HUVECs
| Protein names | Accession no. | Genes | Organism | Log2 FC (R. conorii versus Ctrl) | −log10 P value |
|---|---|---|---|---|---|
| Putative N-acetylmuramoyl-l-alanine amidase RC0497 | Q92IC3 | RC0497 | R. conorii | 6.54 | 5.51 |
| Aldo-keto reductase family 1 member C3 | P42330 | AKR1C3 | Homo sapiens | 5.69 | 5.14 |
| C-X-C motif chemokine 3 | P19876 | CXCL3 | H. sapiens | 5.34 | 4.30 |
| Keratin, type I cytoskeletal 16 | P08779 | KRT16 | H. sapiens | 4.99 | 4.05 |
| IL-6 | P05231 | IL6 | H. sapiens | 4.99 | 7.61 |
| Granulocyte colony-stimulating factor | P09919 | CSF3 | H. sapiens | 4.47 | 5.29 |
| Galectin-7 | P47929 | LGALS7 | H. sapiens | 4.38 | 4.76 |
| Keratin, type II cuticular Hb5 | P78386 | KRT85 | H. sapiens | 4.33 | 6.68 |
| Keratin, type II cytoskeletal 8 | P05787 | KRT8 | H. sapiens | 4.33 | 6.33 |
| Growth-regulated α protein | P09341 | CXCL1 | H. sapiens | 4.26 | 4.06 |
| C-C motif chemokine 2 | P13500 | CCL2 | H. sapiens | 4.15 | 6.38 |
| BRISC and BRCA1-A complex member 1 | Q9NWV8 | BABAM1 | H. sapiens | 3.65 | 2.97 |
| TBC1 domain family member 31 | Q96DN5 | TBC1D31 | H. sapiens | 3.60 | 4.52 |
| Intercellular adhesion molecule 1 | P05362 | ICAM1 | H. sapiens | 3.54 | 3.58 |
| C-X-C motif chemokine 2 | P19875 | CXCL2 | H. sapiens | 3.31 | 2.67 |
| IL-8 | P10145 | CXCL8 | H. sapiens | 3.26 | 5.68 |
| Sequestosome-1 | Q13501 | SQSTM1 | H. sapiens | 2.72 | 2.48 |
| PHD finger-like domain-containing protein 5A | Q7RTV0 | PHF5A | H. sapiens | 2.47 | 3.84 |
| Caspase-6 | P55212 | CASP6 | H. sapiens | 2.40 | 3.47 |
| Myelin basic protein | P02686 | MBP | H. sapiens | −2.65 | 2.44 |
| Protein FAM107B | Q9H098 | FAM107B | H. sapiens | −2.70 | 2.88 |
| Insulin | P01308 | INS | H. sapiens | −2.81 | 2.58 |
| Thymosin β-15B | P0CG35 | TMSB15B | H. sapiens | −3.27 | 2.65 |
| Nonhistone chromosomal protein HMG-17 | P05204 | HMGN2 | H. sapiens | −3.29 | 2.25 |
| Protein transport protein Sec61 subunit β | P60468 | SEC61B | H. sapiens | −3.34 | 4.85 |
| Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial | Q9Y6H1 | CHCHD2 | H. sapiens | −3.36 | 3.65 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Q13526 | PIN1 | H. sapiens | −3.89 | 2.60 |
Accession numbers of the proteins in the table are from the Uniprot protein database (http://www.uniprot.org).
Ctrl, control; FC, fold change; HUVEC, human umbilical vein endothelial cell.