Table 2.
The Host Proteins with the Highest Discrimination Power between Controls and SLD and LD Rickettsia conorii Infection
| Protein names | Accession no. | Genes | Log2 FC | −log10 P value |
|---|---|---|---|---|
| SLD versus control | ||||
| Serum amyloid A-2 protein | P05367 | SAA2 | 11.26 | 13.76 |
| Serum amyloid A-1 protein | P05366 | SAA1 | 10.02 | 9.34 |
| Proteoglycan 4 | Q9JM99 | PRG4 | 9.35 | 9.77 |
| Haptoglobin | Q61646 | HP | 8.97 | 10.12 |
| Neutrophil gelatinase-associated lipocalin | P11672 | LCN2 | 8.70 | 7.38 |
| Band 3 anion transport protein | P04919 | SLC4A1 | 8.42 | 6.59 |
| Serum amyloid A-3 protein | P04918 | SAA3 | 8.22 | 7.00 |
| Monocyte differentiation antigen CD14 | P10810 | CD14 | 8.04 | 8.00 |
| α-1-Acid glycoprotein 2 | P07361 | ORM2 | 7.75 | 11.05 |
| Chymotrypsinogen B | Q9CR35 | CTRB1 | 7.05 | 4.76 |
| Glycosylation-dependent cell adhesion molecule 1 | Q02596 | GLYCAM1 | −3.97 | 3.31 |
| Major urinary protein 2 | P11589 | MUP2 | −4.33 | 7.12 |
| Thrombospondin-1 | P35441 | THBS1 | −4.41 | 2.99 |
| α-1B-glycoprotein | Q19LI2 | A1BG | −4.43 | 6.46 |
| Receptor-type tyrosine-protein phosphatase N2 | P80560 | PTPRN2 | −4.77 | 5.47 |
| Major urinary protein 4 | P11590 | MUP4 | −5.20 | 4.17 |
| Major urinary proteins 11 and 8 | P04938 | MUP8 | −6.70 | 4.49 |
| LD versus control | ||||
| Serum amyloid A-2 protein | P05367 | SAA2 | 13.28 | 9.65 |
| Serum amyloid A-1 protein | P05366 | SAA1 | 11.79 | 6.29 |
| Serum amyloid A-3 protein | P04918 | SAA3 | 10.91 | 5.15 |
| Neutrophil gelatinase-associated lipocalin | P11672 | LCN2 | 10.56 | 5.05 |
| Proteoglycan 4 | Q9JM99 | PRG4 | 9.29 | 6.11 |
| Argininosuccinate synthase | P16460 | ASS1 | 9.29 | 5.88 |
| Band 3 anion transport protein | P04919 | SLC4A1 | 9.25 | 5.40 |
| Heat shock protein HSP 90-α | P07901 | HSP90AA1 | 9.15 | 5.51 |
| Triosephosphate isomerase | P17751 | TPI1 | 8.60 | 3.71 |
| Major urinary proteins 11 and 8 | P04938 | MUP8 | −6.42 | 3.93 |
| α-1B-glycoprotein | Q19LI2 | A1BG | −6.63 | 5.65 |
| Major urinary protein 2 | P11589 | MUP2 | −7.00 | 5.52 |
| Insulin-like growth factor–binding protein complex acid labile subunit | P70389 | IGFALS | −7.12 | 3.47 |
| LD versus SLD | ||||
| Uteroglobin | Q06318 | SCGB1A1 | 7.19 | 3.38 |
| Creatine kinase M-type | P07310 | CKM | 5.91 | 3.43 |
| Plasminogen activator inhibitor 1 | P22777 | SERPINE1 | 5.43 | 4.84 |
| Cytosolic 10-formyltetrahydrofolate dehydrogenase | Q8R0Y6 | ALDH1L1 | 5.37 | 4.03 |
| Histone H4 | P62806 | HIST1H4A | 5.26 | 3.80 |
| Argininosuccinate lyase | Q91YI0 | ASL | 5.22 | 3.28 |
| Inorganic pyrophosphatase | Q9D819 | PPA1 | 5.18 | 4.12 |
| Adenylyl cyclase-associated protein 1 | P40124 | CAP1 | 5.17 | 2.56 |
| Estradiol 17 β-dehydrogenase 5 | P70694 | AKR1C6 | 5.03 | 2.23 |
| Nicotinate-nucleotide pyrophosphorylase (carboxylating) | Q91X91 | QPRT | 5.01 | 3.24 |
| Ribonuclease UK114 | P52760 | HRSP12 | 5.01 | 2.10 |
| Tubulin β-4B chain | P68372 | TUBB4B | 4.93 | 4.91 |
| Chymotrypsin-like elastase family member 3B | Q9CQ52 | CELA3B | −4.30 | 3.67 |
| Anionic trypsin-2 | P07146 | PRSS2 | −4.55 | 2.33 |
| Insulin-like growth factor–binding protein complex acid labile subunit | P70389 | IGFALS | −4.68 | 2.96 |
| Carboxypeptidase A1 | Q7TPZ8 | CPA1 | −5.38 | 3.35 |
| BPI fold-containing family A member 2 | P07743 | BPIFA2 | −5.67 | 6.69 |
There were three experimental groups: SLD (n = 6), LD (n = 3), and control (n = 5). Accession numbers of the proteins in the table are from the Uniprot protein database (http://www.uniprot.org).
FC, fold change; LD, lethal dose; SLD, sublethal dose.