Table 1. Pathways that are commonly enriched in PrECs exposed to 5 nM BPA, 25 nM BPA and 0.1 nM EE2. Orange: pathways related to metabolism pathways, green: pathways related to DNA replication and cell cycle, yellow: pathways related to cancer, light blue: pathways related to inflammation and immune response, purple: pathways related to protein biogenesis, dark green: signaling pathways, pink: pathways related to biological adhesion. (The color version of the table is available in the electronic copy of the article).

Pathways Common to All 3 Exposures	5 nM BPA (p-value)	25 nM BPA (p-value)	0.1 nM EE2 (p-value)
Alanine, aspartate and glutamate metabolism	5.11E-03	1.07E-02	9.81E-03
Biosynthesis of amino acids	1.36E-04	8.12E-04	1.70E-03
Carbon metabolism	2.98E-05	1.82E-04	1.04E-03
Cell cycle	9.63E-04	1.82E-03	1.37E-02
Central carbon metabolism in cancer	6.05E-04	1.01E-02	6.84E-03
Chemical carcinogenesis	2.68E-03	7.53E-03	3.01E-02
Cytokine-cytokine receptor interaction	5.00E-03	2.97E-03	1.22E-02
DNA replication	3.88E-06	1.56E-08	1.46E-07
ECM-receptor interaction	5.28E-06	6.99E-06	4.75E-04
HTLV-I infection	2.67E-03	1.69E-03	2.86E-03
Leukocyte transendothelial migration	4.34E-02	1.81E-02	3.71E-02
Metabolic pathways	5.32E-03	1.39E-03	4.28E-04
Mismatch repair	3.63E-02	4.50E-04	7.97E-05
Natural killer cell mediated cytotoxicity	1.60E-02	3.43E-02	4.87E-02
Protein digestion and absorption	4.46E-03	3.00E-03	3.44E-02
Proteoglycans in cancer	1.12E-02	1.06E-02	6.08E-03
Purine metabolism	1.20E-02	2.28E-04	6.75E-04
Pyrimidine metabolism	6.38E-03	1.06E-03	3.82E-03
Regulation of actin cytoskeleton	3.32E-02	2.24E-02	2.58E-02
Ribosome biogenesis in eukaryotes	6.62E-04	1.01E-03	1.28E-02
RNA transport	2.28E-02	3.28E-02	2.45E-02
Small cell lung cancer	4.79E-02	1.74E-02	1.70E-02
TGF-beta signaling pathway	4.30E-02	3.21E-02	4.19E-02