Table 2. Top 30 GO biological process terms that are commonly enriched in PrECs exposed to 5 nM BPA, 25 nM BPA and 0.1 nM EE2. Orange: BP terms related to metabolic pathways, green: BP terms related to DNA replication and cell cycle, light yellow: BP terms related to cancer, dark yellow: BP terms related to embryonic development, light blue: BP terms related to inflammation and immune response, purple: BP terms related to protein biogenesis, turquoise: BP terms related to angiogenesis and blood circulation, pink: pathways related to biological adhesion. (The color version of the table is available in the electronic copy of the article).
|
Biological Process Terms Common
to All 3 Exposures |
5 nM BPA
(p-value) |
25 nM BPA
(p-value) |
0.1 nM EE2
(p-value) |
|---|---|---|---|
| Acute inflammatory response | 3.81E-02 | 1.29E-02 | 2.62E-02 |
| Acylglycerol metabolic process | 3.20E-02 | 2.12E-02 | 7.64E-03 |
| ADP metabolic process | 5.60E-04 | 5.75E-03 | 3.30E-02 |
| Alditol metabolic process | 1.48E-03 | 1.67E-02 | 2.13E-03 |
| Alpha-amino acid metabolic process | 1.83E-02 | 6.40E-03 | 4.39E-02 |
| Ameboidal-type cell migration | 2.64E-03 | 1.49E-02 | 2.58E-02 |
| Aminoglycan catabolic process | 3.25E-03 | 3.59E-03 | 1.58E-02 |
| Anatomical structure development | 8.20E-07 | 1.90E-04 | 1.00E-04 |
| Anatomical structure formation involved in morphogenesis | 2.20E-04 | 2.69E-03 | 4.29E-03 |
| Anatomical structure homeostasis | 8.87E-03 | 2.34E-02 | 1.78E-02 |
| Anatomical structure morphogenesis | 1.40E-04 | 9.77E-03 | 1.01E-02 |
| Angiogenesis | 2.50E-05 | 9.50E-05 | 3.10E-05 |
| Animal organ development | 6.00E-07 | 3.90E-06 | 1.00E-04 |
| Animal organ morphogenesis | 5.76E-03 | 3.09E-03 | 4.65E-03 |
| Animal organ regeneration | 1.57E-03 | 9.07E-03 | 1.85E-02 |
| ATP generation from ADP | 3.70E-04 | 8.19E-03 | 3.75E-02 |
| Attachment of spindle microtubules to kinetochore | 2.08E-02 | 1.60E-03 | 2.64E-02 |
| Biological adhesion | 6.60E-04 | 2.60E-04 | 4.23E-02 |
| Blood circulation | 2.46E-03 | 2.50E-05 | 2.63E-03 |
| Blood vessel development | 1.40E-04 | 1.20E-04 | 1.10E-04 |
| Blood vessel morphogenesis | 9.30E-05 | 1.30E-04 | 5.00E-04 |
| C-terminal protein amino acid modification | 2.50E-03 | 4.89E-02 | 2.02E-02 |
| C-terminal protein lipidation | 1.34E-03 | 3.43E-02 | 2.22E-02 |
| Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | 2.61E-02 | 3.80E-02 | 1.24E-02 |
| Carbohydrate biosynthetic process | 2.13E-02 | 4.60E-04 | 1.39E-03 |
| Carbohydrate metabolic process | 3.50E-05 | 2.40E-05 | 9.25E-03 |
| Carboxylic acid biosynthetic process | 9.28E-03 | 3.70E-05 | 9.00E-04 |
| Carboxylic acid metabolic process | 4.40E-05 | 1.60E-05 | 6.80E-04 |
| Cardiovascular system development | 3.10E-04 | 9.30E-05 | 1.60E-04 |
| Cell adhesion | 4.80E-04 | 2.80E-04 | 3.80E-02 |