Figure 2. Lack of total body irradiation (TBI) mitigation by JP4-039 in Fancg−/− mice. Thirteen Fancg−/− mice (C57BL/6 background) were irradiated to 8.5 Gy TBI. Twenty-four hours later, seven of the mice were injected with 50 μl of JP4-039 dissolved in 30% 2-hydroxypropyl-β- cyclodextrin at a concentration of 8 mg/ml. The mice were followed for the development of hematopoietic syndrome at which time they were sacrificed. There was no significant difference in survival between the groups.
