Figure 3. Lack of total body irradiation (TBI) mitigation by JP4-039 in Fancd2−/− mice. Ten Fancd2−/− on a 129/Sv background were irradiated to 8.5 Gy TBI, and five were injected (50 μl) 24 h later with JP4-039 (20 mg/kg) in 30% 2-hydroxypropyl-β-cyclodextrin (8 mg/ml). The mice were followed for development of hematopoietic syndrome. There was no significant difference in survival between the groups.