Figure 1. Improved survival of mice treated with total body irradiation (TBI) and Lactobacillus reuteri-IL-22 (n=10). Groups of 10 mice received 9.25 Gy TBI then 24 h later gavage of 100 μl of saline containing 109 Lactobacillus reuteri-interleukin (IL-22), or IL-22 protein delivered intraperitoneally at 20 mg/kg in 100 μl, or 100 μl cyclodextrin containing 20 mg/kg of the radiation mitigator JP4-039. Significant increase in survival was seen in irradiated mice treated with JP4-039 (p=0.0079), IL-22 protein (p=0.0428) or Lactobacillus-IL-22 (p=0.0014) but not control Lactobacillus (p=0.5021) compared to control irradiated mice.
