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Principle of nanopore sequencing. Biological nanopores are built into an artificial membrane. In the case of DNA, double-stranded DNA is unzipped by a motor protein before passing through the pore. During sequencing, the sequencer measures current changes at a constant frequency with the movement of a DNA strand and stores current measurements in fast5 files. Ideally, current measurements can be divided into events by red dashed lines, according to the movement of k-mers.
