Fig. 1. Ldts are targets for the treatment of M. tuberculosis. (A) Reaction of the LdtMt2 nucleophilic cysteine with a carbapenem β-lactam antibiotic to form a stable acyl–enzyme complex. (B) Proposed reaction of the LdtMt2 nucleophilic cysteine with fluorogenic probe 1,9 releasing SO2, fluorescein, and arylating the cysteine residue. (C) Structures of the cysteine-reactive reagents tested for inhibition of LdtMt2. Faropenem (11) was included as a positive control.
