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. 2020 Jan 20;10:3120. doi: 10.3389/fimmu.2019.03120

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Copyright © 2020 Gonçalves, Rezende, Oliveira, Ribeiro, Fattori, Silva, Prazeres, Queiroz-Junior, Santana, Costa, Beltrami, Costa, Birbrair, Verri, Lopes, Cunha, Teixeira, Amaral and Pinho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resident macrophage activation and inflammatory molecules gene expression characterizes inflammatory status of DRG after resolution of inflammation in AIA model. Immunized mice received either i.a. injection of mBSA (10 μg/10 μl of PBS) to AIA induction or PBS (10 μl) in control group. (A) Confocal microscopy slides show marked Iba1⁺ cells within DRG (L4) 8 days after AIA induction and (B) its quantification (n = 5). Time course of gene expression of (C) IL-1β, (D) IL-6, (E) CXCL1, (F) COX-2, (G) iNOS, and (H) IL-10 within lumbar DRG (L3–L5). DRG samples from the control group were extracted 8 days after i.a. injection (n = 5). The results are represented as mean ± SEM; p = specified value in the graph compared to control group (PBS) using ANOVA following by Dunnett post-hoc analysis.