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. 2020 Jan 17;10:1534. doi: 10.3389/fphys.2019.01534

FIGURE 2.

FIGURE 2

Expression of EPOR reporter gene in transgenic mice. (A) The proximal promoter region of the human EPOR gene extending to the translation start site with ATG at +135 in the human EPOR gene, contains conserved regulatory binding sites for GATA proteins (AGATAA) and Sp1 (CCGCCC), and 3-E-boxes (CAGCTG) in the 5′ untranslated transcribed region that can bind basic-helix-loop-helix transcription factors such as erythroid TAL1 and skeletal muscle transcription factors Myf5 and MyoD. (B) Transgenic mice containing the human EPOR proximal promoter region extending 1778 bp 5′ of the transcription start site driving the β-galactosidase reporter gene shows EPOR expression in the embryonic brain at embryonic day E9.5 (from Liu et al., 1997, with permission). (C) Reporter gene expression at embryonic day 12.5 (left) and embryonic day 13.5 (right) in the visceral arches, base of limbs, intercostal rib regions, and fetal liver (from Ogilvie et al., 2000, with permission).