FIGURE 3.

Endogenous and exogenous EPO signaling regulates white fat mass accumulation. (A,B) Body weight to 48 weeks of age are indicated for wild type mice (solid line) and mice with EPOR restricted to erythroid tissue (Suzuki et al., 2002) (ΔEpoR_E) (dashed line) for females (A) and males (B). (C,D) Hematocrit (C) and % body weight normalized to starting body weight (D) for male wild type mice subjected to 3 weeks of EPO treatment at 3000 U/kg three times weekly (dashed line) or saline (solid line). Arrow indicates end of EPO treatment. ^∗p < 0.05; ^∗∗p < 0.01 (from Teng et al., 2011b, with permission).