FIGURE 4.

EPO regulation of fat mass is gender specific. (A,B) Cumulative body weight change was monitored in male (A) and female (B) mice (16 weeks) fed high fat diet and treated with EPO at 3000 U/kg three times weekly (solid symbol) or saline (open symbol) for 3 weeks. (C) Cumulative body weight change in female ovariectomized (OVA) mice with placebo (p) or estradiol pellet-supplement and treated with EPO (E) or phosphate-buffered saline (P). ^∗∗p < 0.01; ^#p < 0.001 (from Zhang et al., 2017, with permission).