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. 2019 Sep 18;37(1):195–207. doi: 10.1093/molbev/msz214

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© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 6. — Mutational profile for fluoroquinolone-resistance gyrA mutations is lineage-specific in clinical isolates of Mycobacterium tuberculosis. An initial data set consisting of 3,450 genomes with confirmed MDR-TB mutations were surveyed. About 854 genomes were identified as fluoroquinolone-resistant, with 848 of these genomes containing at least one gyrA mutation. Only fixed fluoroquinolone-resistance mutations in the gyrA gene are enumerated here (n = 710). No fixed mutations were observed in Lineage 5 strains. Numbers of genomes analyzed per lineage are presented directly below their respective bar graph.