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. 2020 Jan 13;2020(1):CD012643. doi: 10.1002/14651858.CD012643.pub3

Comparison 2. Subgroups in univariable comparison of OS: PET+ve vs. PET‐ve.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
2.1 OS by radiotherapy 9 1802 Hazard Ratio (IV, Random, 95% CI) 5.09 [2.64, 9.81]
2.1.1 Involved node and/or site 3 548 Hazard Ratio (IV, Random, 95% CI) 3.45 [1.22, 9.72]
2.1.2 involved field 4 428 Hazard Ratio (IV, Random, 95% CI) 12.75 [4.98, 32.68]
2.1.3 not specified 2 826 Hazard Ratio (IV, Random, 95% CI) 2.80 [1.17, 6.67]
2.2 OS by study design 8 1717 Hazard Ratio (IV, Random, 95% CI) 4.63 [2.43, 8.80]
2.2.1 Prospective 3 406 Hazard Ratio (IV, Random, 95% CI) 5.35 [1.07, 26.68]
2.2.2 Retrospective 4 589 Hazard Ratio (IV, Random, 95% CI) 7.12 [3.14, 16.14]
2.2.3 RCT 1 722 Hazard Ratio (IV, Random, 95% CI) 2.60 [1.03, 6.56]
2.3 OS by chemotherapy 9 1802 Hazard Ratio (IV, Random, 95% CI) 5.09 [2.64, 9.81]
2.3.1 ABVD 5 801 Hazard Ratio (IV, Random, 95% CI) 5.19 [2.11, 12.72]
2.3.2 ABVD and/or other 3 279 Hazard Ratio (IV, Random, 95% CI) 10.30 [1.71, 62.13]
2.3.3 BEACOPP 1 722 Hazard Ratio (IV, Random, 95% CI) 2.60 [1.03, 6.56]
2.4 OS for PET/CT vs PET 8 1706 Hazard Ratio (IV, Random, 95% CI) 5.01 [2.50, 10.02]
2.4.1 PET/CT 5 595 Hazard Ratio (IV, Random, 95% CI) 4.70 [1.86, 11.86]
2.4.2 PET only 3 1111 Hazard Ratio (IV, Random, 95% CI) 6.99 [1.58, 30.90]
2.5 OS by disease stage 9 1802 Odds Ratio (IV, Random, 95% CI) 5.09 [2.64, 9.81]
2.5.1 Stages I and II with A and B symptoms 1 96 Odds Ratio (IV, Random, 95% CI) 9.21 [0.71, 120.03]
2.5.2 All stages 7 984 Odds Ratio (IV, Random, 95% CI) 6.28 [2.62, 15.05]
2.5.3 Advanced 1 722 Odds Ratio (IV, Random, 95% CI) 2.60 [1.03, 6.56]
2.6 Timing of interim PET 9 1802 Hazard Ratio (IV, Random, 95% CI) 5.09 [2.64, 9.81]
2.6.1 PET2 6 1495 Hazard Ratio (IV, Random, 95% CI) 3.53 [1.97, 6.32]
2.6.2 Other (including mixed) 3 307 Hazard Ratio (IV, Random, 95% CI) 20.13 [5.04, 80.38]
2.7 OS by HR type of estimation 9 1802 Hazard Ratio (IV, Random, 95% CI) 5.09 [2.64, 9.81]
2.7.1 precise 7 1638 Hazard Ratio (IV, Random, 95% CI) 5.70 [2.60, 12.48]
2.7.2 Imprecise 2 164 Hazard Ratio (IV, Random, 95% CI) 3.60 [0.89, 14.64]