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. 2020 Jan 13;2020(1):CD012643. doi: 10.1002/14651858.CD012643.pub3

Comparison 3. Subgroups in univariable comparison of PFS: PET+ve vs. PET‐ve.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
3.1 PFS by study design 13 1349 Hazard Ratio (IV, Random, 95% CI) 5.66 [4.02, 7.97]
3.1.1 prospective 3 357 Hazard Ratio (IV, Random, 95% CI) 3.95 [2.23, 7.00]
3.1.2 retrospective 8 827 Hazard Ratio (IV, Random, 95% CI) 6.85 [4.66, 10.08]
3.1.3 RCT 2 165 Hazard Ratio (IV, Random, 95% CI) 6.21 [2.87, 13.42]
3.2 PFS by chemotherapy 14 2079 Hazard Ratio (IV, Random, 95% CI) 4.90 [3.47, 6.90]
3.2.1 ABVD 7 945 Hazard Ratio (IV, Random, 95% CI) 5.13 [3.18, 8.27]
3.2.2 ABVD and/or other 4 265 Hazard Ratio (IV, Random, 95% CI) 7.07 [3.40, 14.70]
3.2.3 other NON‐ABVD chemo 3 869 Hazard Ratio (IV, Random, 95% CI) 3.64 [1.83, 7.24]
3.3 PFS for PET/CT vs PET 13 1983 Hazard Ratio (IV, Random, 95% CI) 5.08 [3.57, 7.21]
3.3.1 PET/CT 8 707 Hazard Ratio (IV, Random, 95% CI) 6.03 [3.68, 9.90]
3.3.2 PET only 5 1276 Hazard Ratio (IV, Random, 95% CI) 4.06 [2.33, 7.08]
3.4 PFS by disease stage 14 2079 Hazard Ratio (IV, Random, 95% CI) 4.90 [3.47, 6.90]
3.4.1 Stages I and II with A and B symptoms 2 184 Hazard Ratio (IV, Random, 95% CI) 3.88 [1.54, 9.83]
3.4.2 All stages 11 1173 Hazard Ratio (IV, Random, 95% CI) 5.81 [3.93, 8.57]
3.4.3 Advanced 1 722 Hazard Ratio (IV, Random, 95% CI) 2.27 [1.35, 3.82]
3.5 PFS by radiotherapy 14 2079 Hazard Ratio (IV, Random, 95% CI) 4.90 [3.47, 6.90]
3.5.1 Involved node and/or site 5 651 Hazard Ratio (IV, Random, 95% CI) 5.35 [2.94, 9.75]
3.5.2 Involved field 6 514 Hazard Ratio (IV, Random, 95% CI) 7.06 [4.15, 12.00]
3.5.3 Not specified 2 826 Hazard Ratio (IV, Random, 95% CI) 2.97 [1.48, 5.98]
3.5.4 None 1 88 Hazard Ratio (IV, Random, 95% CI) 5.09 [1.95, 13.29]
3.6 Timing of interim PET 14 2079 Hazard Ratio (IV, Random, 95% CI) 4.90 [3.47, 6.90]
3.6.1 PET2 9 1677 Hazard Ratio (IV, Random, 95% CI) 4.68 [3.14, 6.98]
3.6.2 Other (including mixed) 5 402 Hazard Ratio (IV, Random, 95% CI) 6.32 [3.40, 11.75]
3.7 PFS by HR type of estimation 14 2079 Hazard Ratio (IV, Random, 95% CI) 4.90 [3.47, 6.90]
3.7.1 precise 9 1450 Hazard Ratio (IV, Random, 95% CI) 4.69 [2.84, 7.73]
3.7.2 Imprecise 5 629 Hazard Ratio (IV, Random, 95% CI) 5.66 [3.65, 8.77]