Study	Definition of progression outcome
Andre 2017	Progression‐free survival, defined – from the date of random assignment to date of progression – as experiencing relapse after previous complete remission or progression after reaching partial remission (50% decrease and resolution of B symptoms and no new lesions); progressive disease (50% increase from nadir of any previous partial remission lesions or appearance of new lesions) on CT scan measurements during protocol treatment; or death from any cause, whichever occurred first.
Casasnovas 2019	Progression‐free survival defined as the time from randomisation to first progression, relapse, or death from any cause or last follow‐up.
Annunziata 2016	The primary endpoint was PFS, with progression during treatment, lack of complete remission at the end of the first‐line treatment, and relapse counted as adverse events.
Barnes 2011; Ying 2014; Zinzani 2012	Progression‐free survival is defined as the time from diagnosis to progression or death from any cause.
Kobe 2018	Progression‐free survival is defined as the time from completion of staging until progression, relapse, or death from any cause, or to the day when information was last received on the patient's disease status.
Cerci 2010	Three‐year event‐free survival was chosen as the endpoint and defined as the time from diagnosis to treatment failure or last follow‐up. Treatment failure was defined as an incomplete response after first‐line treatment, progression during therapy, relapse, or death.
Gallamini 2014; Markova 2012; Mesguich 2016; Oki 2014;	Progression‐free survival is defined as the time from diagnosis to either disease progression or relapse, or to death as a result of any cause, whichever occurred first.
Hutchings 2005; Hutchings 2006	Progression‐free survival is defined as the time from diagnosis to first evidence of progression or relapse, or to disease‐related death.
Okosun 2012	Progression‐free survival is defined as the time from diagnosis to disease progression or relapse or last follow‐up.
Rossi 2014	Progression‐free survival is defined as the time from the beginning of treatment until progression, relapse, or death from any cause or the date of last follow‐up. Time‐to‐progression (TTP) is defined as the time from the date of the first course of chemotherapy to any treatment failure, including progression, relapse, or death related to lymphoma, or the date of the last follow‐up.
Touati 2014	Progression‐free survival is defined as the time from diagnosis to relapse or death.
Hutchings 2014; Simon 2016; Straus 2011; Zaucha 2017	Definition not reported.