Study	Prognostic factors								Adjusted results for interim PET
	Interim PET	Age	Gender	Disease stage	B symptoms	Bulky disease	IPS	Other study‐specific factors
Kobe 2018	x	‐	‐	‐	‐	‐	x	x	Interim PET‐positivity (DS 4) HR 3.2 (95% CI 1.3 to 8.4), P = 0.02 Comment: Adjusted results indicate an independent prognostic impact of PET2.
Simon 2016	x	‐	‐	‐	‐	‐	‐	x	Interim PET‐positivity HR = 11.51 (95% CI 3.14 to 42.86), P < 0.001 Comment: Adjusted results indicate the independent prognostic impact of PET2.
x = prognostic factor considered for adjustment in the final model ‐ = prognostic factor was not considered in the final model