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. 2019 Apr 7;16(1):70–85. doi: 10.1080/15548627.2019.1598750

Figure 8.

Figure 8.

MIR5680 targeted DPP4 and decreased the mRNA level of it. (a) Possible binding sites of MIR5680 in DPP4 3ʹ UTR. (b) Luc-DPP4 3ʹ UTR-WT or Luc-DPP4 3ʹ UTR-Mut plasmids were co-transfected with NC or MIR5680 mimics into HEK293T cells for 24 h. Luciferase activity was determined. (c) After transfection with NC, MIR5680 mimics for 48 h, detecting the mRNA level of DPP4 by qPCR analysis. (d) VECs were treated with HG for 48 h after overexpression or knockdown of CA7-4. qPCR analysis of DPP4 mRNA level. (*, p < 0.05; **, p < 0.01; n = 3.).