Comparison 4. Ibuprofen (oral) vs indomethacin (oral).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Presence of PDA on third day of life (72 hours of treatment)	1	62	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.43, 2.33]
2 Neonatal mortality (at < 28 days)	1	62	Risk Ratio (M‐H, Fixed, 95% CI)	2.0 [0.19, 20.93]
3 IVH all grades	1	62	Risk Ratio (M‐H, Fixed, 95% CI)	0.11 [0.01, 1.98]
4 IVH (grade III or IV)	1	62	Risk Ratio (M‐H, Fixed, 95% CI)	0.2 [0.01, 4.00]
5 NEC	1	62	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.22, 4.58]
6 GI bleeding	1	62	Risk Ratio (M‐H, Fixed, 95% CI)	0.25 [0.03, 2.11]
7 Hospitalisation (days)	1	62	Mean Difference (IV, Fixed, 95% CI)	10.20 [1.24, 19.16]