Date	Event	Description
12 November 2018	New search has been performed	This updates the review titled "Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants," which was published in the Cochrane Library, Issue 7, 2011 (Ohlsson 2011)
12 November 2018	New citation required and conclusions have changed	Two new studies have been added in this update, and the review conclusions have been changed
2 April 2011	New search has been performed	This updates the review titled "Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants," which was published in the Cochrane Library, Issue 3, 2009 (new reference)
2 April 2011	New citation required and conclusions have changed	The updated search identified 1 additional trial for inclusion in the review. The review now includes 2 trials of prophylactic ibuprofen administered orally and 5 trials with IV administration Oral administration of ibuprofen appears as effective as IV administration. Risk of upper gastrointestinal bleed may be higher with orally administered ibuprofen
28 February 2009	New search has been performed	This updates the review titled "Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants," which was published in the Cochrane Library, Issue 1, 2006 (Shah 2006) The updated search identified 2 additional trials for inclusion in this review No changes were made to the conclusion of this review
22 September 2005	New citation required and conclusions have changed	Substantive amendments were made