Summary of findings 8. Class‐based compared to age‐based HPV vaccination in schools.

Comparison 8: class‐based compared to age‐based HPV vaccination in schools
Population: adolescents Setting: Tanzania Intervention: class‐based vaccination Comparison: age‐based vaccination
Outcomes	Impact				№ of participants (studies)	Certainty of the evidence (GRADE)**
	Absolute effects* (95% CI)		Relative effect (95% CI)	Narrative results
	With age‐based delivery	With class‐based delivery
HPV vaccine uptakea	721 per 1000	786 per 1000 (764 to 815)	RR 1.09 (1.06 to 1.13)	Class‐based vaccination probably leads to slightly higher HPV vaccine uptake than age‐based vaccination.	5537 (1)b	⊕⊕⊕⊝ Moderatec
CI: confidence interval; HPV: human papillomavirus; RR: risk ratio. *The anticipated absolute effects in the intervention group (and its 95% CI) is based on the likelihood of being vaccinated in the comparison group and the relative effect of the intervention (and its 95% CI). **GRADE Working Group grades of evidence: High certainty: this research provides a very good indication of the likely effect. The likelihood that the effect will be substantially different† is low. Moderate certainty: this research provides a good indication of the likely effect. The likelihood that the effect will be substantially different† is moderate. Low certainty: this research provides some indication of the likely effect. However, the likelihood that it will be substantially different† is high. Very low certainty: this research does not provide a reliable indication of the likely effect. The likelihood that the effect will be substantially different† is very high. †Substantially different = a large enough difference that it might affect a decision

^a The lag‐time between delivery of the intervention and assessment of outcomes was 12 months.

^bWatson‐Jones 2012 (cluster‐randomised trial).
 ^c Downgraded one level for indirectness, given that the outcome is based on one study from one setting.