Szilagyi 2015.

Methods	Randomised trial in the USA
Participants	Participants: providers Number per group: PBRN consisted of 10 practices; 5 intervention and 5 controls while from the national paediatric continuity clinic PBRN (CORNET) consisted of 12 practices; 6 intervention, 6 controls. Number enrolled: 22 practices Study population: 22 practices were allocated in 1 of 2 PBRNs to provider prompts or standard‐of‐care control. 10 primary care practices participated, 5 intervention and 5 controls, each matched in pairs on urban, suburban, or rural location and practice type (paediatric or family medicine), from a PBRN in Greater Rochester, NY (GR‐PBRN); and 12 practices, 6 intervention, 6 controls, similarly matched, from a national paediatric continuity clinic PBRN (CORNET).
Interventions	Intervention: EHR prompt Description: the EHR display a prompt on the screen when a healthcare provider opens each of the patient's EMRs. In the study, all prompts used the same algorithm and displayed a list of vaccines due at that visit. Prompts did not generally show prior vaccinations and did not include standing orders. For each intervention practice, between 1‐ and 2‐hour educational sessions was given to the providers to inform them about EHR‐based prompts. Duration: 12‐month Comparison: usual practice Description: providers in the control practices received standard of care, which did not include prompts Vaccine target: Tdap, MCV4, HPV, and influenza vaccines Disease targeted: meningitis, HPV, influenza, tetanus, diphtheria, pertussis Number of doses: 3 doses for HPV. Others not specified
Outcomes	Uptake of Tdap; MCV4; HPV1, 2, and 3; and influenza vaccines
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	SAS software program used to randomly allocate to the intervention or control.
Allocation concealment (selection bias)	Low risk	Using Stata 12.1, 1 author (AB) randomly assigned practices within each PBRN and practice pair to be an intervention or a standard of care control practice.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	The outcome is an objective measure.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Healthcare providers were unaware of group assignment and the intervention was delivered by trained patient immunisation navigators.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Loss of 1 practice pair from the GR‐PBRN and refusal rates were similar for intervention and control practices.
Selective reporting (reporting bias)	Low risk	Probably no selective reporting.
Other bias	Low risk	No other bias.