Esposito 2018.

Methods	Randomised trial in Italy
Participants	Participants: adolescents aged 11–13 years Number per group: 334 participants in no intervention group, 281 participants in website educational programme only, and 302 participants in website educational programme plus the face‐to‐face lesson Total number enrolled: 917 adolescents Study population: over 1 school year, involving 4 secondary schools for adolescents aged 11–13 years and 8 schools for adolescents 14–18 years old in Milan, Italy.
Interventions	Intervention: education intervention on adolescent vaccines Description: registration of vaccination coverage and attitudes toward vaccination at the beginning and at the end of the school year plus participation in a presentation and access to a specific website dedicated to vaccines and vaccination; the procedures described in arm 2 plus participation in a lecture on vaccines and vaccination from medical experts in classrooms. Duration: 1 school year Comparison: no education intervention on adolescent vaccines Description of comparison: registration of vaccination coverage and attitudes toward vaccination at the beginning and at the end of the school year, but no intervention Vaccine target: diphtheria, tetanus, pertussis and HPV vaccines Disease targeted: cervical cancer and tetanus, pertussis and diphtheria Number of doses: not specified
Outcomes	Adolescent vaccines uptake Knowledge and attitude on adolescent vaccines
Notes

HPV: human papillomavirus.