Al Sebaey 2012.
| Methods | Randomised clinical trial | |
| Participants | Country: Egypt
Period of recruitment: not stated
Number randomised: 125
Post‐randomisation dropouts: not stated
Revised sample size: 125
Average age (years): 50
Females: 56 (44.8%)
Ascites grade 2: 0 (0.0%)
Ascites grade 3: 125 (100.0%)
Refractory or recurrent ascites: not stated
Alcohol‐related cirrhosis: not stated
Viral‐related cirrhosis: not stated
Autoimmune disease‐related cirrhosis: not stated
Other causes for cirrhosis: not stated Prophylactic antibiotics for subacute bacterial peritonitis: not stated Exclusion 1. Hypertension 2. Cardiac or respiratory disease 3. Other features of decompensation |
|
| Interventions | Group 1: Paracentesis plus systemic vasoconstrictors (n = 50) Further details: Large volume paracentesis (details not available) + terlipressin 1 mg at onset of LVP, 8 hours, and 16 hours or midodrine 5 to 10 mg orally TDS for 3 days) Group 2: Paracentesis plus fluid replacement (n = 75) Further details: Large volume paracentesis (no further details) + HES or low dose albumin or high dose albumin | |
| Outcomes | None of the outcomes of interest were reported. | |
| Notes | Source of funding: not stated Trial name/trial registry number: not stated Attempts were made to contact the authors in November 2018. | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Comment: this information was not available. |
| Allocation concealment (selection bias) | Unclear risk | Comment: this information was not available. |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Comment: this information was not available. |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Comment: this information was not available. |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Comment: this information was not available. |
| Selective reporting (reporting bias) | Unclear risk | Comment: pre‐published protocol was not available. |
| Other bias | Low risk | Comment: no other bias noted |