Wada 1996.

Methods	4‐week washout period 8‐week before‐and‐after study
Participants	19 men and women with type IIa and IIb hyperlipidaemia age ≥ 20 years TC ≥ 220 mg/dL (5.69 mmol/L) Exclusion criteria: statin hypersensitivity, hypothyroidism, Cushing's syndrome, obstructive gallbladder disease, SLE, nephrosis, HDL seborrhoea, drug‐induced hyperlipidaemia, diet therapy for obesity, secondary hyperlipidaemia, alcohol abuse Cerivastatin 0.15 mg/d baseline TC: 6.90 mmol/L (267 mg/dL)
Interventions	Cerivastatin 0.15 mg/d evening dosing
Outcomes	Percentage change from baseline at 4‐8 weeks of blood TC
Source of funding	Unknown
Notes	LDL‐C, HDL‐C and TG were not included in the efficacy analysis because the given values and the calculated values differed by > 10%
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Controlled before‐and‐after design
Allocation concealment (selection bias)	High risk	Controlled before‐and‐after design
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Lipid parameter measurements unlikely influenced by lack of blinding
Blinding of outcome assessment (detection bias) LDL‐C	Low risk	Lipid parameters were measured in a remote laboratory
Blinding of outcome assessment (detection bias) WDAE	High risk	No comparison possible
Incomplete outcome data (attrition bias) Total cholesterol	Low risk	[(19‐18)/19)*100 = 5.3% participants were not included in the efficacy analysis
Incomplete outcome data (attrition bias) LDL cholesterol	High risk	Excluded because was not included in the efficacy analysis because the given values and the calculated values differed by > 10%
Incomplete outcome data (attrition bias) HDL cholesterol	High risk	Excluded because was not included in the efficacy analysis because the given values and the calculated values differed by > 10%
Incomplete outcome data (attrition bias) Triglycerides	High risk	Excluded because was not included in the efficacy analysis because the given values and the calculated values differed by > 10%
Selective reporting (reporting bias)	High risk	LDL‐C outcome was not reported
Other bias	Unclear risk	Source of funding not reported