Bianchi 1999.
| Methods | No. of centres: 1
Location: University of Milan, Italy Recruitment period: July 1994 to October 1996 |
|
| Participants | Inclusion criteria: < 40 yrs Exclusion criteria: medical or surgical treatment for endometriosis, concurrent disease that might affect fertility or cause pelvic pain, women without pain symptoms, women not seeking pregnancy, liver or endocrine disease No. randomised: 77 No. analysed: 77 | |
| Interventions | Post‐surgical medical therapy 1. Danazol oral 600 mg daily x 3/12 (n = 36) 2. No treatment (n = 41) | |
| Outcomes | Pain recurrence AFS scores Pregnancy rates Adverse events of medication | |
| Notes | Power calculation: NS Funding: NS | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | "Randomization was done according to a computer generated list" |
| Allocation concealment (selection bias) | Unclear risk | not mentioned |
| Blinding (performance bias and detection bias) All outcomes | High risk | not mentioned, no placebo |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | all randomised patients included in analysis |
| Selective reporting (reporting bias) | Low risk | important outcomes ‐ pregnancy rate and recurrence of endometriosis pain, adverse effects reported |
| Other bias | Low risk | groups appear comparable at baseline |