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. 2004 Jul 19;2004(3):CD003678. doi: 10.1002/14651858.CD003678.pub2

Bianchi 1999.

Methods No. of centres: 1 
 Location: University of Milan, Italy
Recruitment period: July 1994 to October 1996
Participants Inclusion criteria: < 40 yrs 
 Exclusion criteria: medical or surgical treatment for endometriosis, concurrent disease that might affect fertility or cause pelvic pain, women without pain symptoms, women not seeking pregnancy, liver or endocrine disease 
 No. randomised: 77 
 No. analysed: 77
Interventions Post‐surgical medical therapy 
 1. Danazol oral 600 mg daily x 3/12 (n = 36) 
 2. No treatment (n = 41)
Outcomes Pain recurrence 
 AFS scores 
 Pregnancy rates 
 Adverse events of medication
Notes Power calculation: NS 
 Funding: NS
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk "Randomization was done according to a computer generated list"
Allocation concealment (selection bias) Unclear risk not mentioned
Blinding (performance bias and detection bias) 
 All outcomes High risk not mentioned, no placebo
Incomplete outcome data (attrition bias) 
 All outcomes Low risk all randomised patients included in analysis
Selective reporting (reporting bias) Low risk important outcomes ‐ pregnancy rate and recurrence of endometriosis pain, adverse effects reported
Other bias Low risk groups appear comparable at baseline