Busacca 2001.

Methods	Location: University of Milan, Italy No. of centres: 1 Recruitment period: July 1997 to December 1999
Participants	Inclusion criteria: < 40 yrs, laparoscopic diagnosis of endometriosis stage III‐IV Exclusion criteria: previous medical or surgical therapy for endometriosis, other diseases that might affect fertility or cause pelvic pain; liver, endocrine or neoplastic disease No. randomised: 89 No. analysed: 89
Interventions	Post‐surgical medical therapy Gr A (n=44): leuprolide acetate SC 3.5 mg 4 weekly x 3 doses Gr B (n=45): no treatment
Outcomes	Pain: pelvic pain recurrence at 18/12 AFS scores: objective disease recurrence Cumulative pregnancy rates at 18/12
Notes	Power calculation: yes Funding: NS
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"randomization was performed according to a computer generated list unknown to the physicians"
Allocation concealment (selection bias)	Unclear risk	not described
Blinding (performance bias and detection bias) All outcomes	High risk	not mentioned, no placebo
Incomplete outcome data (attrition bias) All outcomes	Low risk	all randomised patients included in the analysis
Selective reporting (reporting bias)	Low risk	important outcomes of pregnancy and recurrence of endometriosis and pain reported
Other bias	Low risk	groups appear comparable at baseline