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. 2004 Jul 19;2004(3):CD003678. doi: 10.1002/14651858.CD003678.pub2

Donnez 1994.

Methods No. of centres: 1 
 Location: Catholic University of Louvain, Belgium
Recruitment period: January 1990 to December 1990
Participants Inclusion criteria: age < 35 yrs, infertility, laparoscopic confirmed ovarian endometriotic cysts (AFS moderate n = 41, AFS severe n = 39) 
 Exclusion criteria: none 
 No. randomised: 80 
 No. analysed: 80
Interventions Medical therapy pre‐surgery 
 1. Goserelin S/C 4 weekly x 4 (n = 40) 
 2. No therapy (n = 40)
Outcomes AFS scores: total, implants, adhesions, moderate, severe scores 
 Ovarian cyst diameter 
 Degree of active endometriosis as determined histologically from ovarian cyst wall biopsy
Notes Power calculation: NS 
 Funding: Fonds de la Recherche Scientifique
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk "randomised according to official randomisation tables"
Allocation concealment (selection bias) Unclear risk not mentioned
Blinding (performance bias and detection bias) 
 All outcomes High risk not mentioned, no placebo used
Incomplete outcome data (attrition bias) 
 All outcomes Low risk all randomised patients included in outcome assessment
Selective reporting (reporting bias) Unclear risk AFS scores at second look laparoscopy ‐ no pregnancy data reported
Other bias Low risk groups appear comparable at baseline