Donnez 1994.
| Methods | No. of centres: 1
Location: Catholic University of Louvain, Belgium Recruitment period: January 1990 to December 1990 |
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| Participants | Inclusion criteria: age < 35 yrs, infertility, laparoscopic confirmed ovarian endometriotic cysts (AFS moderate n = 41, AFS severe n = 39) Exclusion criteria: none No. randomised: 80 No. analysed: 80 | |
| Interventions | Medical therapy pre‐surgery 1. Goserelin S/C 4 weekly x 4 (n = 40) 2. No therapy (n = 40) | |
| Outcomes | AFS scores: total, implants, adhesions, moderate, severe scores Ovarian cyst diameter Degree of active endometriosis as determined histologically from ovarian cyst wall biopsy | |
| Notes | Power calculation: NS Funding: Fonds de la Recherche Scientifique | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | "randomised according to official randomisation tables" |
| Allocation concealment (selection bias) | Unclear risk | not mentioned |
| Blinding (performance bias and detection bias) All outcomes | High risk | not mentioned, no placebo used |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | all randomised patients included in outcome assessment |
| Selective reporting (reporting bias) | Unclear risk | AFS scores at second look laparoscopy ‐ no pregnancy data reported |
| Other bias | Low risk | groups appear comparable at baseline |