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. 2004 Jul 19;2004(3):CD003678. doi: 10.1002/14651858.CD003678.pub2

Loverro 2008.

Methods Location: Italy 
 No. of centres: one
Recruitment period: January 1998 to January 1999
Participants Inclusion criteria: women of reproductive age with stage III ‐ IV endometriosis, associated with chronic pelvic pain,adnexial mass or infertility, who had undergone complete laparoscopic excision, had rAFS score > 15 and no previous hormonal treatment 
 Exclusion criteria: 
 No. randomised: 60 
 No. analysed: 54
Interventions Post‐operative triptorelin versus placebo 
 Gr A (n=29): triptorelin 3.75 mg depot monthly on day 20 of cycle for 3 months 
 Gr B (n=25): placebo monthly on day 20 of cycle for 3 months
Outcomes Pain persistence, pregnancy
Notes Power calculation: NS
Funding: NS
Email sent to contact author Feb 2010 requesting further information ‐ no reply received
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk "using a computer generated randomization table"
Allocation concealment (selection bias) Unclear risk not mentioned
Blinding (performance bias and detection bias) 
 All outcomes Low risk patients were blinded to treatment allocation. placebo injections used
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk 1 and 5 patients lost to follow up from triptorelin and no treatment groups respectively. Possibility of bias
Selective reporting (reporting bias) Low risk pain, relapse and pregnancy reported (for those who desired pregnancy)
Other bias Low risk groups appear similar at baseline