Loverro 2008.
| Methods | Location: Italy
No. of centres: one Recruitment period: January 1998 to January 1999 |
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| Participants | Inclusion criteria: women of reproductive age with stage III ‐ IV endometriosis, associated with chronic pelvic pain,adnexial mass or infertility, who had undergone complete laparoscopic excision, had rAFS score > 15 and no previous hormonal treatment Exclusion criteria: No. randomised: 60 No. analysed: 54 | |
| Interventions | Post‐operative triptorelin versus placebo Gr A (n=29): triptorelin 3.75 mg depot monthly on day 20 of cycle for 3 months Gr B (n=25): placebo monthly on day 20 of cycle for 3 months | |
| Outcomes | Pain persistence, pregnancy | |
| Notes | Power calculation: NS Funding: NS Email sent to contact author Feb 2010 requesting further information ‐ no reply received |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | "using a computer generated randomization table" |
| Allocation concealment (selection bias) | Unclear risk | not mentioned |
| Blinding (performance bias and detection bias) All outcomes | Low risk | patients were blinded to treatment allocation. placebo injections used |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | 1 and 5 patients lost to follow up from triptorelin and no treatment groups respectively. Possibility of bias |
| Selective reporting (reporting bias) | Low risk | pain, relapse and pregnancy reported (for those who desired pregnancy) |
| Other bias | Low risk | groups appear similar at baseline |