Parazzini 1994.

Methods	Location: University centres in Italy No. of centres: 6 Recruitment period: January 1990 to July 1991
Participants	Inclusion criteria: age < 38 yrs, normal medical examination, unexplained infertility for at least 1 year, with/without chronic pelvic pain, endometriosis stage III‐IV, partners with normal sperm analysis and post‐coital tests Exclusion criteria: previous laparoscopic/clinical diagnosis of endometriosis, other diseases that might cause infertility or pelvic pain, previous treatment for endometriosis or infertility No. randomised: 75 No. analysed: 75 (pregnancy rates), 68 (pain scores)
Interventions	Post‐surgical medical therapy Gr A (n=36): nafarelin nasal 400 μg daily x 3/12 Gr B (n=39): placebo
Outcomes	Pain (multidimensional and 10‐point linear scale) score at 12 months Pregnancy rates Adverse drug outcome (amenorrhoea)
Notes	Power calculation: yes (post‐hoc?) Funding: Recordati Milan provided nafarelin
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"computer generated randomization list"
Allocation concealment (selection bias)	Low risk	assigned by telephone call 7 days from surgery
Blinding (performance bias and detection bias) All outcomes	Low risk	double blind but authors acknowledge that adverse effects of treatment make maintaining blinding difficult
Incomplete outcome data (attrition bias) All outcomes	Low risk	no losses to follow up, all randomised patients included in analyses
Selective reporting (reporting bias)	Low risk	pregnancy rate and pelvic pain reported
Other bias	Low risk	groups appear comparable at baseline