Yang 2006.
| Methods | Location: Harbin, China
No. of centres: one Recruitment period:March 2002 to March 2004 |
|
| Participants | Inclusion criteria: women with stage 3 endometriosis who had undergone conservative or semi‐conservative surgery, with normal renal function and blood count, aged 23 to 42 Exclusion criteria: history of hypertension, heart disease, diabetes mellitis, had undergone hormone therapy in 6 months prior to surgery No. randomised: 52 No. analysed: unclear | |
| Interventions | Post‐operative
Gr A (n=20): yiweining (YWN) 200 ml orally twice daily, for 3 months, starting on 7th post‐operative day
Gr B (n=19): gestrinone 2.5 mg twice weekly, SC? for 3‐6 months, starting on 7th post‐operative day Gr C (n=13): control ‐ no treatment |
|
| Outcomes | Pregnancy, recurrence of endometriosis, adverse effects | |
| Notes | Power calculation: not stated
Funding: Fund of National Science of Heilongjiang Province Email sent to corresponding author requesting additional information April 2010 ‐ mailbox not found |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | "randomly divided" ‐ no details of method of sequence generation given |
| Allocation concealment (selection bias) | Unclear risk | not mentioned |
| Blinding (performance bias and detection bias) All outcomes | High risk | not mentioned, no placebo used |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | not clear how many of the randomised patients are included in the outcomes (% only given) |
| Selective reporting (reporting bias) | Unclear risk | pregnancy and recurrence reported ‐ no details as criteria for measuring these |
| Other bias | Low risk | groups are similar in age and type of surgery at baseline |
NS = not stated IM = intramuscular
SC = subcutaneous