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. 2020 Jan 16;2020(1):CD013125. doi: 10.1002/14651858.CD013125.pub2
Database Time span Search strategy
Central Register of Controlled Trials (CENTRAL) in the Cochrane Library Issue 11, 2018 #1 MeSH descriptor: [Antibiotic Prophylaxis] explode all trees
#2 antibiotic*
#3 antibacteri* near prophyl*
#4 #1 or #2 or #3
#5 MeSH descriptor: [Liver Cirrhosis] explode all trees
#6 ((hepatic or liver) and (fibrosis or cirrhosis or cirrhotic))
#7 #5 or #6
#8 #4 and #7
MEDLINE Ovid January 1947 to November 2018 1. exp antibiotic prophylaxis/
2. antibiotic*.ti,ab.
3. (antibacteri* adj prophyl*).ti,ab.
4. 1 or 2 or 3
5. exp Liver Cirrhosis/
6. ((hepatic or liver) and (fibrosis or cirrhosis or cirrhotic)).ti,ab.
7. 5 or 6
8. 4 and 7
9. randomized controlled trial.pt.
10. controlled clinical trial.pt.
11. randomized.ab.
12. placebo.ab.
13. drug therapy.fs.
14. randomly.ab.
15. trial.ab.
16. groups.ab.
17. 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16
18. exp animals/ not humans.sh.
19. 17 not 18
20. 8 and 19
Embase Ovid January 1974 to November 2018 1. exp antibiotic prophylaxis/
2. antibiotic*.ti,ab.
3. (antibacteri* adj prophyl*).ti,ab.
4. 1 or 2 or 3
5. exp liver cirrhosis/
6. ((hepatic or liver) and (fibrosis or cirrhosis or cirrhotic)).ti,ab.
7. 5 or 6
8. 4 and 7
9. exp crossover‐procedure/ or exp double‐blind procedure/ or exp randomized controlled trial/ or single‐blind procedure/
10. (((((random* or factorial* or crossover* or cross over* or cross‐over* or placebo* or double*) adj blind*) or single*) adj blind*) or assign* or allocat* or volunteer*).af.
11. 9 or 10
12. 8 and 11
Science Citation Index Expanded (Web of Science) January 1945 to November 2018 #1 TS=(antibiotic*)
 #2 TS=(antibacteri* near prophyl*)
 #3 #2 OR #1
 #4 TS=((hepatic or liver) and (fibrosis or cirrhosis or cirrhotic))
#5 TS=(random* OR rct* OR crossover OR masked OR blind* OR placebo* OR meta‐analysis OR systematic review* OR meta‐analys*)
#6 #3 AND #4 AND #5
World Health Organization International Clinical Trials Registry Platform (apps.who.int/trialsearch/Default.aspx) November 2018 Condition: cirrhosis; intervention: antibiotic*
ClinicalTrials.gov November 2018 antibiotic | Interventional Studies | Cirrhosis | Phase 2, 3, 4
European Medical Agency (www.ema.europa.eu/ema/) and US Food and Drug Administration (www.fda.gov) November 2018 spontaneous bacterial peritonitis