Comparison 10. Guselkumab 200 mg vs placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Proportion of participants cleared or almost cleared in the short term	2	154	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.15, 9.30]
2 Proportion of participants with adverse effects serious or severe enough to have caused withdrawal of participants from the study	1	49	Risk Ratio (M‐H, Random, 95% CI)	2.88 [0.32, 25.80]
3 Proportion of participants achieving a 50% reduction in disease severity	1	49	Risk Ratio (M‐H, Random, 95% CI)	2.88 [1.24, 6.69]